EARLY WHOLE-BODY MAGNETIC RESONANCE IMAGING IN THE STAGING OF CANCER
Publication Date
03.08.2010
Nature of Contract
Service contract
Deadline
30.09.2010
Date of Document
Place of Delivery
,
Region
UK: SOUTH EAST (ENGLAND)
I.D.:
6108828
Type of Document
Tender (all procedures)
Description
Introduction The aim of the HTA programme is to ensure that high quality research information on the effectiveness, costs and broader impact of health technologies is produced in the most efficient way for those who use, manage, provide care in or develop policy for the NHS. Topics for research are identified and prioritised to meet the needs of the NHS. Health technology assessment forms a substantial portfolio of work within the awarding authroity and each year about fifty new studies are commissioned to help answer questions of direct importance to the NHS. The studies include both primary research and evidence synthesis. Question In selected patients with a new diagnosis of cancer does early whole-body magnetic resonance imaging (WB-MRI) lead to a more rapid detection of distant metastases and better staging of tumours 1 Technology: Whole-body magnetic resonance imaging (WB-MRI). 2 Patient group: Newly diagnosed adult patients with lung cancer or colorectal cancer. 3 Setting: Secondary care in-patients or out-patients. 4 Comparators: Proposals to describe the combination of modalities in the `standard? diagnostic pathway (typically including PET/CT where used) / time. 5 Design: A cohort study to assess the diagnostic accuracy and costs of early use of WB-MRI to replace a series of existing tests ?early? in the diagnostic pathway. Proposals should clearly describe the existing pathway and grouping of tests being compared and explore whether early WB-MRI might be effective at replacing a number of existing imaging tests in the diagnostic pathway and reducing the time to major treatment decisions. Applicants will need to give careful consideration and describe at what point in time and how WB-MRI tests are to be handled to ensure the integrity of the study. 6 Important outcomes: Comparison of test accuracy of `pathways? for metastases, time to definitive staging, significant changes in patient management, occurrence of incidental findings, patient acceptability, an economic evaluation. 7 Minimum duration of follow-up: 12 months. Background to commissioning brief: Whole-body magnetic resonance imaging (WB-MRI) represents a new approach to the existing stepwise multi-modality approach for staging of malignancies. A number of studies have shown that for some cancers it might provide an alternative to some current diagnostic techniques and there are a large number of patients who might potentially benefit from this approach. WB-MRI has been compared with conventional imaging (a combination of chest computerised tomography (CT) scan, scintigraphy or Fludeoxyglucose-Positron emission tomography (FDG-PET) and abdominal/pelvic CT scan/MRI). WB-MRI may provide an acceptable ?one-stop" investigation, reducing the time spent in waiting for and undergoing tests. This could represent a cost-effective use of resourceconventional staging investigations.
CPV
73110000, 73210000, 85140000
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